i-heart-j2m:

ephemeral-castiel:

castiel-knight-of-hell:

d0n7fr37:

Why is the only thing sam has a crayon. WHY A CRAYON OF ALL THINGS

because it can’t be used as a weapon. A pen or pencil can be stabbed into someone if you use enough force. Aim for the jugular and it can be deadly

Try and stab someone with a crayon and the worst you can do is give them a small bruise

Crowley looks so affronted by being given a crayon of all things. 

This was my favorite thing in the episode.

(via justcallmepotato)


winchysteria:


In the Flesh script caps 1/?

but really guys think about this?? if kieren would be 22 right now, as his gravestone indicates, bill banned him from the macy house when he was fourteen.
fourteen.
he’s just out of secondary/middle school?? and he paints all the time?? and he loves hardcore metal music and punk rock outfits with weird buckles on them?? and let’s be honest he probably weighs like eighty pounds soaking wet this boy is a tiny little oddball kieren puppy
and then rick macy who is two years older than him and all handsome and sporty and popular and and his dad is canonically the most terrifying man in roarton but weentsy little kieren decides “yes this is the one. this is the one i will love”
so he makes him a mix cd
MY HEART

winchysteria:

In the Flesh script caps 1/?

but really guys think about this?? if kieren would be 22 right now, as his gravestone indicates, bill banned him from the macy house when he was fourteen.

fourteen.

he’s just out of secondary/middle school?? and he paints all the time?? and he loves hardcore metal music and punk rock outfits with weird buckles on them?? and let’s be honest he probably weighs like eighty pounds soaking wet this boy is a tiny little oddball kieren puppy

and then rick macy who is two years older than him and all handsome and sporty and popular and and his dad is canonically the most terrifying man in roarton but weentsy little kieren decides “yes this is the one. this is the one i will love”

so he makes him a mix cd

MY HEART

(via inconsistentblogger)


thespectacularspider-girl:

feignedaffections:

allthingshyper:

gehayi:

hiddlesbatchlove:

forever-falling-forward:

platredeparis:

bnycolew:

mannysiege:

Progress

What

Imma just let this sit here

MOTHA FUCKIN SCIENCE

sources:
Engagdget
DailyTech
CBS

They turned RNA into an anti-virus program. That is amazing.

Let me restate this in case it didn’t sink in the first time
Researchers physically DELETED ALL TRACES of the HIV virus from a human cell.
ALL OF IT.
IF YOU ARE NOT EXCITED ABOUT THAT I DON’T THINK YOU KNOW WHAT HIV IS

Here is the original paper.  My computer at work is currently being an ass.( http://www.hivdent.org/_research_/2014/PNAS-2014-Hu-1405186111.pdf.)
 “Our results also demonstrate, for the first time to our knowledge, that Cas9/gRNA genome editing can be used to immunize cells against HIV-1 infection. The preventative vaccination is independent of HIV-1 strain’s diversity because the system targets genomic sequences regardless of how the viruses enter the infected cells.”
 “Here, we found that LTR-directed gRNA/  Cas9 eradicates the HIV-1 genome and effectively immunizes target cells against HIV-1 reactivation and infection with high specificity and efficiency. These properties may provide a viable path toward a permanent or “sterile” HIV-1 cure, and perhaps provide a means to eradicate and vaccinate against other pathogenic viruses.”
This is beyond awesome.  Not only does it cure HIV infection, it immunizes other cells.  They believe it can be applied to other viral infections where the virus integrates into the host’s genome.

Lets think about this for a second.  HIV was first confirmed in 1959, retroactively, by examining the deceased’s preserved blood.  Between 1960 and 1980, HIV and AIDS are both relatively unknown, with many cases only confirmed retroactively by symptoms or studying the deceased years after their death.
In 1980, we have “Patient Zero” in the USA.  This is when HIV/AIDS became publicly known.
1980.  It is now 2014.  34 years.  It took us only 34 years, from widespread knowledge to this first major step in a cure.  34 years.  Just slightly longer than a generation we have fought HIV to this extent.
And we are only going to get better at it. 

thespectacularspider-girl:

feignedaffections:

allthingshyper:

gehayi:

hiddlesbatchlove:

forever-falling-forward:

platredeparis:

bnycolew:

mannysiege:

Progress

What

Imma just let this sit here

MOTHA FUCKIN SCIENCE

sources:

Engagdget

DailyTech

CBS

They turned RNA into an anti-virus program. That is amazing.

Let me restate this in case it didn’t sink in the first time

Researchers physically DELETED ALL TRACES of the HIV virus from a human cell.

ALL OF IT.

IF YOU ARE NOT EXCITED ABOUT THAT I DON’T THINK YOU KNOW WHAT HIV IS

Here is the original paper.  My computer at work is currently being an ass.
( http://www.hivdent.org/_research_/2014/PNAS-2014-Hu-1405186111.pdf.)

 “Our results also demonstrate, for the first time to our knowledge, that Cas9/gRNA genome editing can be used to immunize cells against HIV-1 infection. The preventative vaccination is independent of HIV-1 strains diversity because the system targets genomic sequences regardless of how the viruses enter the infected cells.”

 “Here, we found that LTR-directed gRNA/  Cas9 eradicates the HIV-1 genome and effectively immunizes target cells against HIV-1 reactivation and infection with high specificity and efficiency. These properties may provide a viable path toward a permanent orsterileHIV-1 cure, and perhaps provide a means to eradicate and vaccinate against other pathogenic viruses.”

This is beyond awesome.  Not only does it cure HIV infection, it immunizes other cells.  They believe it can be applied to other viral infections where the virus integrates into the host’s genome.

Lets think about this for a second.  HIV was first confirmed in 1959, retroactively, by examining the deceased’s preserved blood.  Between 1960 and 1980, HIV and AIDS are both relatively unknown, with many cases only confirmed retroactively by symptoms or studying the deceased years after their death.

In 1980, we have “Patient Zero” in the USA.  This is when HIV/AIDS became publicly known.

1980.  It is now 2014.  34 years.  It took us only 34 years, from widespread knowledge to this first major step in a cure.  34 years.  Just slightly longer than a generation we have fought HIV to this extent.

And we are only going to get better at it. 

(via avengersofgallifrey)


deedragonlvr:

adoxographist:

mogchi:

Hello there, August.

Behind my abs are….. BETTER ABS.

because it’s too amusing to not reblog

(via avengersofgallifrey)


tigerlizii:

fromthemindofatwentyorotherlycan:

tamorapierce:

barrylyga:

yainterrobang:

LIST OF THE WEEK: TWENTY BANNED BOOKS
Celebrate your intellectual freedom. Read a banned book.

Learn more about each book here: The Absolutely True Diary of a Part-Time Indian, Looking for Alaska, I Hunt Killers, Eleanor & Park, Gossip Girl, The Hunger Games, TTYL, 13 Reasons Why, The Giver, Speak, Hold Still, Whale Talk, The Miseducation of Cameron Post, Twenty Boy Summer, Boy Meets Boy, Living Dead Girl, Fallen Angels, Vampire Academy, The Supernaturalist, A Wrinkle In Time.

For more fun lists and all things YA lit, visit our website, follow us here and on Twitter, and subscribe to our weekly newsletter!

I’m surprised when any book is banned or challenged, but the continual obsession with challenging The Absolutely True Diary of a Part-Time Indian absolutely stupefies me. That book has the tamest sexual content I’ve ever seen. I’m stunned people can find anything to object to.

They banned a book about soldiers for profanity?  What’s next, a soldier’s right to breathe?

It’s almost like they’re banning everything that doesn’t fit into their fantasy worldview of a perfect little world where everything is just perfect and OK.

Most adults are stupid like that. They don’t want children learning about the real world because they think kids aren’t smart and can’t handle things that might happen later on in their lives.

(via avengersofgallifrey)




voldesnorts:

harlequin-dreams:

womxxn:

We went to this burger place for lunch (turned out to be a drag bar which was shitty in other ways) but the walls were papered with rolling stones covers and it just really becomes obvious when you see lots of magazine covers next to each other that men are treated as people and women are treated as objects.

THIS PROVES MY POINT SO HARD IT SMASHES YOU IN THE TEETH

GOSH DARN IT I HOPE YOU FEEL THE SLAP IN YOUR FACE

(via justcallmepotato)


i-march-mello:

danim4ux:

THE SHEET IS MADE OUT OF WOOD TOO
Wendell Castle, Ghost Clock. 1985

THAT IS MAHOGANY

i-march-mello:

danim4ux:

THE SHEET IS MADE OUT OF WOOD TOO

Wendell Castle, Ghost Clock. 1985

THAT IS MAHOGANY

(via avengersofgallifrey)


iphone backgrounds


Dylan this is not how you promote a movie

(via justcallmepotato)


Behind the scenes of The Maze Runner [x]

(via justcallmepotato)





« Nobody else is going to die. Not for me. »

« Nobody else is going to die. Not for me. »

(via anondracomalfoy)